And she gave birth to her firstborn son and wrapped him in swaddling cloths and laid him in a manger, because there was no place for them in the inn (Luke 2:7 ESV).

Even in his birth, Jesus there was no room or space given for Jesus among his people.  The rejection of Jesus is reiterated in chapter four of Luke when he is rejected at Nazareth.  After reading from Isaiah and stating that he is the fulfillment of the scriptures he read (21) they marvel at his word (22).  When they realize he is Joseph's son he predicts his rejection and then goes on to describe three Old Testament instances when Gods people reject God prophet, God sends them to Gentiles!.  Though they are spiritually blind, the see the implication of these examples - God is rejecting them! 
Thought we may not reject him as our Lord and Savior, I wonder how often we reject his ministry, his Lordship in our lives life on a daily basis and miss the grace for change?